Local businesses and nonprofits will line the street for the block party, scheduled to run from 6 to 9:30 p.m.
The Sun Kings, a Beatles tribute band, will play from 6:30 to 8 p.m. in Fremont Park, on Santa Cruz Avenue at University Drive.
Santa Cruz Avenue will be closed to traffic from El Camino Real to University Avenue. Restaurants will extend tables into the street for plaza-style dining.
Activities will include a children's area and a community stage, where non-professional groups will perform. The "Old Tom" fire engine will be on hand for kids to explore and the city of Menlo Park will present displays from several departments.
The block party is coordinated by the Menlo Park Chamber of Commerce.